N,N'-(((oxybis(ethane-2,1-diyl))bis(oxy))bis(propane-3,1-diyl))bis(3-(4,5-dibromo-2-methyl-3,6-dioxo-3,6-dihydropyridazin-1(2H)-yl)propanamide) RDC-8153 Fine-tuning thio-pyridazinediones as SMDC scaffolds

Fine-tuning thio-pyridazinediones as SMDC scaffolds (with intracellular thiol release via a novel self-immolative linker)

1259-1262 DOI: 10

Backbone Modification

Facile Access to Branched Multispecific Proteins Bioconjugate Chem

Preparation of bispecific antibody-protein adducts by site-specific chemo-enzymatic conjugation

N,N'-(((oxybis(ethane-2,1-diyl))bis(oxy))bis(propane-3,1-diyl))bis(3-(4,5-dibromo-2-methyl-3,6-dioxo-3,6-dihydropyridazin-1(2H)-yl)propanamide) RDC-8153 Fine-tuning thio-pyridazinediones as SMDC scaffoldsReferences: Lee, M. T. W.; et al. Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering Chem. Sci. (2017), 8, 2056 2060 DOI: 10. 1039 C6SC03655D Keywords: Antibody Conjugates; Dibromopyridazinedione; Re bridging